GoodTaste
Key Member
- Joined
- Feb 19, 2016
- Member Type
- Student or Learner
- Native Language
- Chinese
- Home Country
- China
- Current Location
- China
Science Magazine offers a headline of "Wound healing headway" on its homepage. By clicking it, it jumps to the content as below:
Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration
Source: https://immunology.sciencemag.org/content/5/50/eaba5683
Wound healing headway
Wound healing in mammalian skin often results in fibrotic scars, and the mechanisms by which original nonfibrotic tissue architecture can be restored are not well understood. Here, Wei et al. have shown that pharmacological activation of the nociceptor TRPA1, which is found on cutaneous sensory neurons, can limit scar formation and promote tissue regeneration. They confirmed the efficacy of TRPA1 activation in three different skin wounding mouse models, and they also observed that localized activation could generate a response at distal wound sites. TRPA1 activation induced IL-23 production by dermal dendritic cells, which activated IL-17–producing γδ T cells and promoted tissue regeneration. These findings provide insight into neuroimmune signaling pathways in the skin that are critical to mammalian tissue regeneration.
===============================
Does "headway" here mean "progress (that is slow and difficult)"?
Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration
Source: https://immunology.sciencemag.org/content/5/50/eaba5683
Wound healing headway
Wound healing in mammalian skin often results in fibrotic scars, and the mechanisms by which original nonfibrotic tissue architecture can be restored are not well understood. Here, Wei et al. have shown that pharmacological activation of the nociceptor TRPA1, which is found on cutaneous sensory neurons, can limit scar formation and promote tissue regeneration. They confirmed the efficacy of TRPA1 activation in three different skin wounding mouse models, and they also observed that localized activation could generate a response at distal wound sites. TRPA1 activation induced IL-23 production by dermal dendritic cells, which activated IL-17–producing γδ T cells and promoted tissue regeneration. These findings provide insight into neuroimmune signaling pathways in the skin that are critical to mammalian tissue regeneration.
===============================
Does "headway" here mean "progress (that is slow and difficult)"?
Last edited by a moderator: