I am not a teacher.
There are lots of differences. As usual, context matters.
How about it? --- a way of asking for a decision
What about it? --- a way of asking for further information
How about Mariana? --- a way of commending her (can also mean "what about")
What about Mariana? --- a way of suggesting her
I could do that forever. Both are highly idiomatic, and there is much crossover in meaning; they are often interchangeable.