crease vs. wrinkle

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tree123

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creases around the eyes

If I replace 'creases" with 'wrinkles", will the meaning of the sentence be changed?

What is the difference between the two words?

The quoted sentence is from my dictionary.
 
In this usage, I would say no- the meaning is the same. In fact, I would more likely use wrinkles than creases to refer to the effects of aging on skin. If you are talking about clothing however, the meaning is quite different. A crease would be a (usually single) line put in with an iron on purpose to create an accent line. Wrinkles come from wearing clothes or not storing them properly.
 
I would use "My clothes are really creased" if they had, for example, been screwed up in a ball on the floor before I put them on. I wouldn't use "wrinkled" but it's not wrong.
 
My dad had plenty of wrinkles. I wouldn't have called them creases.
 
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