notwithstanding the latest's being

[Superguay]

Hi all,

In my writing I go on to enumerate some factors that are popularly considered to be implicated in the occurrence of diseases and then I want to finish the list by adding an annotation by way of an afterthought:

It is widely agreed that in a disease's onset a variety of factors come into play, of which are worthy of mention A, B, C and D—notwithstanding the latest's being reckoned as/to be a result of the rest.

I) Can I get rid of the possessive after notwithstanding? I know that these possessives are often being omitted in spoken English, but is it the case with written English too?

II) Which of the next options sounds less clunky: reckoned as... OR reckoned to be...OR neither

 

[Raymott]

"It is widely agreed that in a disease's onset a variety of factors come into play, of which are worthy of mention A, B, C and D—notwithstanding the latest's being reckoned as/to be a result of the rest."

"It is widely agreed that, in the onset of a disease, a variety of factors come into play. Worthy of mention are A, B, C, and D - although the last factor is usually considered to be a result of the first three."

That's how I might write it. "Latest" refers to time, not to the last on a list. You could use "latter" if there were only two factors.
If "notwithstanding" is necessary, "notwithstanding that the last factor is ..."; "notwithstanding the last being..." (No, you don't need the possessive here.)

"Which of the next options sounds less clunky?"
"Which of the following options ..." "considered to be" is less clunky and more natural.