GoodTaste
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Is the word TRAIL a pun here referring to path and the ligand named TRAIL?
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Finding a TRAIL to allergy control
House dust mites (HDMs) are a major source of aeroallergens that trigger human allergic responses including asthma. To characterize the heterogeneity of human CD4+ T helper (TH) cell responses to HDM antigens, Seumois et al. stimulated blood T cells with HDM peptides and isolated the freshly activated T cells for single-cell RNA sequencing. A TH subset expressing an interferon response gene signature (designated THIFNR) and the cell death–inducing TRAIL ligand was more frequent in individuals without HDM allergy. This TRAIL+ THIFNR subset may function to restrain allergic TH2 responses. Individuals with both HDM allergy and asthma were enriched for interleukin-9–producing TH2 cells. These findings provide a basis for designing more precise approaches to thwart pathogenic TH responses contributing to allergic asthma.
Source: Science
https://immunology.sciencemag.org/content/5/48/eaba6087
=================
Finding a TRAIL to allergy control
House dust mites (HDMs) are a major source of aeroallergens that trigger human allergic responses including asthma. To characterize the heterogeneity of human CD4+ T helper (TH) cell responses to HDM antigens, Seumois et al. stimulated blood T cells with HDM peptides and isolated the freshly activated T cells for single-cell RNA sequencing. A TH subset expressing an interferon response gene signature (designated THIFNR) and the cell death–inducing TRAIL ligand was more frequent in individuals without HDM allergy. This TRAIL+ THIFNR subset may function to restrain allergic TH2 responses. Individuals with both HDM allergy and asthma were enriched for interleukin-9–producing TH2 cells. These findings provide a basis for designing more precise approaches to thwart pathogenic TH responses contributing to allergic asthma.
Source: Science
https://immunology.sciencemag.org/content/5/48/eaba6087
