Not in his state of mind.

[B45]

Should it be:

Talking about taking prescription drugs:

Not in his state of mind.

Not with his state of mind.

 

[Raymott]

You'd really need a sentence to choose between those. What's it got to do with prescription drugs?

 

[B45]

You'd really need a sentence to choose between those. What's it got to do with prescription drugs?

He's depressed and I'm afraid he'll take too much and overdose.

 

[MikeNewYork]

I would say "not in a normal state of mind".

 

[emsr2d2]

I don't think your original fragment is impossible in a conversation.

- Would you recommend that he take XXX drug?
- Not in his (current) state of mind, no.

 

[B45]

So, not with his state of mind is wrong?

 

[emsr2d2]

We speak of people being in a particular state of mind.