systemic ketamine

[GoodTaste]

Does "systemic" here mean "of, or relating to, the nervous system"?


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Deep posteromedial cortical rhythm in dissociation
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In testing for causal significance, we found that rhythmic optogenetic activation of retrosplenial cortex layer 5 neurons recapitulated dissociation-like behavioural effects. Local retrosplenial hyperpolarization-activated cyclic-nucleotide-gated potassium channel 1 (HCN1) pacemakers were required for systemic ketamine to induce this rhythm and to elicit dissociation-like behavioural effects. In a patient with focal epilepsy, simultaneous intracranial stereoencephalography recordings from across the brain revealed a similarly localized rhythm in the homologous deep posteromedial cortex that was temporally correlated with pre-seizure self-reported dissociation, and local brief electrical stimulation of this region elicited dissociative experiences. These results identify the molecular, cellular and physiological properties of a conserved deep posteromedial cortical rhythm that underlies states of dissociation.

Source: Nature Sep.16, 2020
https://www.nature.com/articles/s41586-020-2731-9

 

[tzfujimino]

The passage is highly technical - I don't really understand what it means.

Do you, GoodTaste?

 

[GoodTaste]

Since it is simply a summary, so it is basically popular science and understandable.

One needs to check out a few phrases in Wikipedia of course (just stick to popular science).

 

[jutfrank]

I'm fairly sure it's about the way the drug has been administered into the blood stream. The idea is that the drug is in the system.

I might be wrong, however.


NOT A MEDICAL EXPERT

 

[jutfrank]

Since it is simply a summary, so it is basically popular science and understandable.

No, it certainly is not! It's highly technical, to be read by medical professionals only.

 

[Rover_KE]

Find a medical forum for threads like this.

Thread closed.

 

[GoesStation]

Since it is simply a summary, [STRIKE]so[/STRIKE] it is basically popular science and understandable.

That's entirely incorrect. The text is the abstract of a scientific paper. As such, it's technical and not meant to be understandable by untrained readers.

 

[Tdol]

Systemic:
Denoting the part of the circulatory system concerned with the transport of oxygen to and carbon dioxide from the body in general, especially as distinct from the pulmonary part concerned with the transport of oxygen from and carbon dioxide to the lungs.
Oxford Languages