GoodTaste
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- Feb 19, 2016
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Omicron Neutralization after the Third Vaccine Dose
Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.
Source: New England Journal of Medicine (the above is picked up from its homepage and it might be blocked if you visit it from the USA. The content of the correspondece is here (titled "Plasma Neutralization of the SARS-CoV-2 Omicron Variant) which reads "...Previously, we showed that approximately 20 changes introduced into a synthetic polymutant spike protein (PMS20) are sufficient for substantial evasion of the polyclonal neutralizing antibodies elicited in the majority of persons who have recovered from coronavirus disease 2019 (Covid-19) or have received two doses of an mRNA vaccine..."
Does "resistant" refer to "resistant (against neutralization of antibody)"?
Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.
Source: New England Journal of Medicine (the above is picked up from its homepage and it might be blocked if you visit it from the USA. The content of the correspondece is here (titled "Plasma Neutralization of the SARS-CoV-2 Omicron Variant) which reads "...Previously, we showed that approximately 20 changes introduced into a synthetic polymutant spike protein (PMS20) are sufficient for substantial evasion of the polyclonal neutralizing antibodies elicited in the majority of persons who have recovered from coronavirus disease 2019 (Covid-19) or have received two doses of an mRNA vaccine..."
Does "resistant" refer to "resistant (against neutralization of antibody)"?
