GoodTaste
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Does "thought" here mean "considered"? Is this thought process reflected in some forms (like written form or conversation that can be kept as evidence)?
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We saw this in the Reproducibility Project: Cancer Biology, in which we managed attempts to replicate experiments from high-impact papers1. Among the 50 replication experiments completed (from 23 papers), one required transplanting leukaemia cells into immunocompromised mice and letting the cells grow before administering a potential treatment. Neither our team, the reviewers nor the original authors thought that the immunosuppression technique we proposed, which differed from that in the original study, would affect the key question of whether the treatment lengthened survival2. Until we did the replication and observed no difference in survival3. Then, the reviewers said that this difference was crucial.
Source: Nature 21 JULY 2020
https://www.nature.com/articles/d41586-020-02142-6
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We saw this in the Reproducibility Project: Cancer Biology, in which we managed attempts to replicate experiments from high-impact papers1. Among the 50 replication experiments completed (from 23 papers), one required transplanting leukaemia cells into immunocompromised mice and letting the cells grow before administering a potential treatment. Neither our team, the reviewers nor the original authors thought that the immunosuppression technique we proposed, which differed from that in the original study, would affect the key question of whether the treatment lengthened survival2. Until we did the replication and observed no difference in survival3. Then, the reviewers said that this difference was crucial.
Source: Nature 21 JULY 2020
https://www.nature.com/articles/d41586-020-02142-6
