Salutation

Which one is correct M/s. Freight Company Ltd., or
M/S Freight Company Ltd., and

Dear Sirs for M/S Freight Company or
Dear Sir for M/S Freight Company

[Casiopea]

You'll need to find out how the company writes it. Both M/S and M/s. (acronyms for motor ship) are used. For example,

M/s Freight Masters Alliance, CA, India
M/S Freightair Services, CA, India

[Ouisch]

Also, it may be a female reading your letter. To be honest, when I worked in purchasing years ago, I automatically put the bids and proposals addressed simply "Dear Sir" at the bottom of the pile for consideration. It's more business-like to address it "Dear Sir or Madam."

[Casiopea]

This is interesting--and comical: Transblawg: Dear Sir or Madam/Anrede

[Ouisch]

Great link, Cas! After reading that, I'm leaning towards the non-gender specific "Yo!" as a greeting.

[Barb_D]

Since text speak seems to be taking over the nation, how about skipping the greeting and just saying:

Wassup? How r u?

And then getting into the matter at hand?