"Is anything the matter?".

[keannu]

I have never heard "Is anything the matter?". Do you ever say like this?
M: ⓐ____________ You don't look well.
G: I have a terrible cold.
M: I think you ⓑshould go home and rest.
G: But the class is not over yet.
M: ⓒ___________. You can go.


Choose the right expressions for the blank.① Is anything the matter? ② What does it matter?
③ What's the matter?
④ What's wrong?
⑤ Does it really matter who did it?

 

[Chicken Sandwich]

I have never heard "Is anything the matter?". Do you ever say like this?

"Is anything the matter?" is correct and natural.